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Triclabendazole
Triclabendazole
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Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten, both manufactured by Novartis) is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group.
Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver flukes.
Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.
Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat Fasciola hepatica (both immature and adult liver flukes), roundworms and ectoparasites, as well.
| 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole | |
| Micromedex Detailed Consumer Information | |
| ? | |
| ? | |
| ? | |
| oxidation to the sulfone and sulfoxide parent compound | |
| 22 - 24 hs | |
| >95% in faeces, 2% in urine, and < 1% in milk | |
| 68786-66-3 | |
| P02BX04 QP52AC01 | |
| CID 50248 | |
| 45565 Y | |
| 4784C8E03O Y | |
| CHEMBL1086440 Y | |
| C14H9Cl3N2OS | |
| 359.658 | |
| eMolecules & PubChem | |
| InChI[show | |
Triclabendazole
